Reformatsky reaction is a formation of ß-hydroxy ester when treating ɑ-halo ester with zinc metal in presence of an inert solvent,
Reaction Mechanism of Reformatsky Reaction
In the first step, Zinc metal (0) is reacted with ɑ-halo ester and forms an organo-zinc complex which is simply known as Reformatsky enolate. It is very much similar to a Grignard reagent, It is added to Carbonyl compound and it forms a ß-hydroxy ester
This naming reaction is also undergoing dehydration same as Perkin, aldol reactions to give ɑ, ß – unsaturated esters.
General Information’s about Reformatsky Reaction
- This reaction was usually done with Carbonyl compounds like aldehydes, ketones.
- The reagent is Zinc Metal
- The solvent is an inert solvent like Diethyl ether
- The reactants are carbonyl compounds with ɑ-halo ester
- This involves the formation of Organo-zinc complex
- The product formed in this reaction is a ß-hydroxy ester
To know about the scientist who discovered this wonderful reaction to the chemical science was Sergey Nikolaevich Reformatsky
Originally posted 2022-10-28 09:25:00.