Reformatsky Reaction – Full Reaction Mechanism Explained

Reformatsky Reaction

Reformatsky reaction is a formation of ß-hydroxy ester when treating ɑ-halo ester with zinc metal in presence of an inert solvent,

Reaction Mechanism of Reformatsky Reaction

In the first step, Zinc metal (0) is reacted with ɑ-halo ester and forms an organo-zinc complex which is simply known as Reformatsky enolate. It is very much similar to a Grignard reagent, It is added to Carbonyl compound and it forms a ß-hydroxy ester
This naming reaction is also undergoing dehydration same as Perkin, aldol reactions to give ɑ, ß – unsaturated esters.Reformatsky reaction mechanism,

General Information’s about Reformatsky Reaction

  • This reaction was usually done with Carbonyl compounds like aldehydes, ketones.
  • The reagent is Zinc Metal
  • The solvent is an inert solvent like Diethyl ether
  • The reactants are carbonyl compounds with ɑ-halo ester
  • This involves the formation of Organo-zinc complex
  • The product formed in this reaction is a ß-hydroxy ester

To know about the scientist who discovered this wonderful reaction to the chemical science was Sergey Nikolaevich Reformatsky
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